NeuroMab™ Anti-Lgi1 BBB Shuttle Antibody, Clone N283/7
[CAT#: NRZP-0423-ZP242]
- Species Reactivity:
- Rat; Mouse; Human
- Applications:
- WB; IHC; ICC
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-LGI1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 37-113 (LRRNT domain and first LRR repeat) of mouse Lgi1 (also known as Leucine-rich glioma-inactivated protein 1, Epitempin-1, EPT and UNQ775/PRO1569, accession number Q9JIA1)
Rat: 100% identity (77/77 amino acids identical)
Human: 98% identity (76/77 amino acids identical)
~50% identity with Lgi2, Lgi3 and Lgi4
Rat: 100% identity (77/77 amino acids identical)
Human: 98% identity (76/77 amino acids identical)
~50% identity with Lgi2, Lgi3 and Lgi4
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Rat; Mouse; Human
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
N283/7
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with Lgi2, Lgi3 or Lgi4 (based on KO validation results)
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
LGI1
Official Name
LGI1
Full Name
Lgi1
Alternative Names
LGI1; ADLTE; ADPAEF; ADPEAF; EPITEMPIN; EPT; ETL1; IB1099; leucine-rich; glioma inactivated 1; leucine rich glioma inactivated 1
Uniprot ID
Q9JIA1
Product Pictures
IB
Fig. 1 Immunoblot versus whole brain homogenates (homo) from adult rat and WT and Lgi1 KO mouse probed with N283/7 TC supe.
IHC
Fig. 2 Adult rat hippocampus immunohistochemistry under standard protocol (left) and with antigen retrieval via citrate pretreatment (right).
IB
Fig. 3 Adult rat brain membrane immunoblot.
Publications
Publications (0)
Neural Antibodies
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
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