NeuroMab™ Anti-Lhx6.1 BBB Shuttle Antibody, Clone N228A/16

[CAT#: NRZP-0423-ZP243]

Species Reactivity:: Mouse

Applications:: WB; IHC; ICC

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Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-LHX6 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 347-363 (LDGPLSSRGEKVILFQY, C-terminus) of mouse Lhx6.1A (also known as LIM/homeobox protein Lhx6.1 and Lhx6, accession number Q9R1R0)
Rat: 94% identity (16/17 amino acids identical)
Human: 88% identity (15/17 amino acids identical)
No identity with Lhx6.1B

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N228A/16

Applications

WB; IHC; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

LHX6

Official Name

LHX6

Full Name

Lhx6.1

Alternative Names

LIM/homeobox protein Lhx6

Uniprot ID

Q9R1R0

Product Pictures

Fig. 1 Transfected cell immunoblot: extracts of COS cells transiently transfected with Myc-tagged Lhx6.1 and untagged Kv2.1 plasmids and probed with N228A/16 (left) and 19E10 (right) TC supe.

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