NeuroMab™ Anti-LILRB2 BBB Shuttle Antibody(NRZP-1022-ZP3551)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG

Applications

WB; ELISA; FC; IHC; Inhib; Block; In Vitro

Relevant Diseases

Alzheimer's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

LILRB2

Official Name

LILRB2

Full Name

LILRB

Alternative Names

LILRB2; ILT4; MIR10; LIR2; MIR-10; LIR-2; leukocyte immunoglobulin like receptor B2; ILT-4; CD85D

Product Pictures

ELISA

Figure 1 shows ELISA binding of HLA-G tetramers to LILRB1-Fc and LILRB2-Fc proteins in the presence of HLA-G blocking antibodies.

ELISA

Figure 2 ELISA binding of anti-LILRB antibodies to full-length extracellular LILRB1 proteins Lilrb1_01, Lilrb1_02 and Lilrb1_03.

ELISA

Figure 3 shows ELISA binding of anti-LILRB antibodies to full-length extracellular LILRB2 proteins Lilrb2_01, Lilrb2_02, Lilrb2_03 and Lilrb2_04.

ELISA

Figure 4 shows ELISA binding of anti-LILRB antibodies to full-length extracellular LILRB3 proteins Lilrb3_01 and Lilrb3_05.

ELISA

Figure 5 shows proliferation of T cells in a mixed lymphocyte reaction (MLR) setting by exemplary anti-LILRB2 antibodies 13H1.G2 and 6G6.H7.

ELISA

Figure 6 shows IFNγ production by exemplary anti-LILRB2 antibodies 13H1.G2 and 6G6.H7 and pan-anti-LILRB1/2/3 antibody 9C9.E6 in a two-way mixed lymphocyte reaction (MLR) setup.

ELISA

Figure 7 illustrates ELISA binding of exemplary anti-LILRB antibodies to full-length extracellular LILRB2-Fc(d1-d4), LILRB2_d1d2-Fc, or LILRB2_d3d4-Fc protein.

Publications