NeuroMab™ Anti-Navbeta2 Na+ channel BBB Shuttle Antibody, Clone N395/68

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-SCN2B BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-215 (full-length) of mouse Navbeta2 (also known as Sodium channel subunit beta-2, Scn2b, UNQ326/PRO386 and Gm183, accession number Q56A07)
Rat: 97% identity (209/215 amino acids identical)
Human: 92% identity (198/215 amino acids identical)
<30% identity with Navbeta1, Navbeta3 or Navbeta4

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

N395/68

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with Navbeta1, Navbeta3 or Navbeta4 (based on KO validation results)

Research Areas

Na+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

SCN2B

Official Name

SCN2B

Full Name

Navbeta2 Na+ channel

Alternative Names

Sodium Voltage-Gated Channel Beta Subunit 2; Sodium Channel; Voltage-Gated; Type II; Beta Polypeptide; Sodium Channel; Voltage Gated; Type II Beta Subunit; Sodium Channel; Voltage-Gated; Type II; Beta Subunit; Neuronal Voltage-Gated Sodium Channel Beta 2 Subunit; Sodium Channel; Voltage-Gated; Type II; Beta; Sodium Channel Subunit Beta-2; ATFB14;

Uniprot ID

Q56A07

Product Pictures

Fig. 1 Immunoblot against crude membranes from adult rat brain (RBM) and wild-type (WT) and Navbeta2 knockout (KO) mouse brains probed with N395/68 TC supe.

Fig. 2 Immunoblot against crude membranes from adult rat brain (RBM) and wild-type (WT) and Navbeta2 knockout (KO) mouse brains probed with N52A/42 TC supe.