NeuroMab™ Anti-Notch 1 Antibody(NRP-0422-P1833)

Product Overview

Description

The antibody specifically binds the extracellular domain of human Notch1. The anti-Notch1 antibody has value as potential cancer therapeutics.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

IHC; ELISA; In Vitro

Relevant Diseases

Alzheimer's Disease; Epilepsy; Pain

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

> 95% (SDS-PAGE)

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

Notch1

Official Name

NOTCH1

Full Name

NOTCH1

Alternative Names

Notch 1; Translocation-Associated Notch Protein TAN-1; TAN1; HN1; Notch (Drosophila) Homolog 1 (Translocation-Associated); Notch Homolog 1; Translocation-Associated (Drosophila); Notch Homolog 1; Translocation-Associated;

Gene ID

4851 (Human); 18128 (Mouse); 25496 (Rat)

Uniprot ID

P46531 (Human); Q01705 Mouse (Mouse); Q07008 Rat (Rat)

Product Pictures

FuncS

Figure 1. Lactate dehydrogenase assay results from adenoid cystic carcinoma subjects treated with anti-Notch1 antibody OMP-52M51.

FuncS

Figure 2. Liver CT scans of subjects with adenoid cystic carcinoma before and after treatment with the anti-Notch1 antibody OMP-52M51.

FuncS

Figure 3. Notch1 signal detection.

IHC

Figure 4. Immunohistochemical detection of Notch1 ICD. Figure 4A. Positive control tumor OMP-B40. Figure 4B. Negative control tumor OMP-C11. Figure 4C. Tumors in ACC patients.

Publications