NeuroMab™ Anti-QKI-5-NLS BBB Shuttle Antibody, Clone N195A/16

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-QKI BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 315-331 (ATKVRRHDMRVHPYQRI, with nuclear localization signal underlined) of human QKI-5 (also known as Protein quaking, HqkI and Hqk, accession number Q96PU)
Mouse: 100% identity (17/17 amino acids identical)
Rat: 100% identity (17/17 amino acids identical)
No identity with QKI-6, QKI-7 and QKI-7b

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N195A/16

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with QKI-6, QKI-7 or QKI-7b;Cross-reacts with other STAR proteins containing similar nuclear localization signals

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

QKI

Official Name

QKI

Full Name

QKI-5

Alternative Names

QKI; KH Domain Containing RNA Binding; HqkI; Hqk; Homolog Of Mouse Quaking QKI (KH Domain RNA Binding Protein); Quaking Homolog; KH Domain RNA Binding (Mouse); Quaking Homolog; KH Domain RNA Binding; QKI/LOC100132735 Fusion;

Uniprot ID

Q96PU8

Product Pictures

Fig. 1 Transfected cell immunoblot: extracts of COS cells transiently transfected with Flag-tagged QKI-5, QKI6, QKI-7 and QKI-7b and untagged Kv2.1 plasmids and probed with N195A/16 TC supe (left) and mouse antiFlag (right).