NeuroMab™ Anti-Shank1/ SPANK-1/Synamon/SSTRIP scaffold protein BBB Shuttle Antibody, Clone N22/21

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-SHANK1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 469-691 (SH3/PDZ domains) of rat Shank1 (accession number Q9WV48)
Human: 96% identity (215/223 amino acids identical)
Mouse: 100% identity (223/223 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N22/21

Applications

WB; IHC; ICC

Application Notes

No crossreactivity against Shank2 or Shank3

Research Areas

Scaffolds

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

SHANK1

Official Name

SHANK1

Full Name

Shank1

Alternative Names

SH3 And Multiple Ankyrin Repeat Domains 1; Somatostatin Receptor-Interacting Protein; SSTR-Interacting Protein; SSTRIP; SH3 And Multiple Ankyrin Repeat Domains Protein 1; SPANK-1; Synamon; Shank1;