NeuroMab™ Anti-Zinedin/Striatin-4 BBB Shuttle Antibody, Clone K88/64

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Striatin 4 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 42-354 of human Zinedin/Striatin-4 (accession number Q9NRL3)
Rat: 95% identity (300/313 amino acids identical)
Mouse: 96% identity (300/313 amino acids identical)
52% identity with human Striatin-3

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

K88/64

Applications

WB; IHC; IP; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Striatin 4

Official Name

STRN4

Full Name

Zinedin

Alternative Names

STRN4; ZIN; zinedin; PPP2R6C; striatin 4

Uniprot ID

Q9NRL3

Product Pictures

Fig. 1 Immunoblot on adult rat brain membranes.

IHC

Fig. 2 Adult rat hippocampus immunohistochemistry.

Fig. 3 Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].