NeuroMab™ Rat Anti-Mouse CD140b Monoclonal Antibody (CBP2282)
[CAT#: NAB2010214LS]
Anti-CD140b Monoclonal Antibody [APC]
- Host Species:
- Rat
- Species Reactivity:
- Mouse
- Applications:
- FC
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
Platelet-derived growth factor receptor-β (PDGFR-β), CD140b, is one of two receptors for platelet-derived growth factors (PDGFs) and binds to all isoforms of PDGFs. PDGFRβ is a receptor tyrosine kinase that forms homodimers or heterodimers on the surface upon ligand binding and phosphorylates substrates. PDGFRs consist of either homodimers of α/α, β/β, or heterodimers of α/β. PDGF receptors, α and β, are single glycoproteins with intracellular tyrosine kinase domain. Their ligand, PDGF, is a mitogen for connective tissue and glial cells. CD140b is expressed on embryonic tissues and mesenchymal-derived cells adult mice. PDGF plays a role in wound healing and acts as a chemoattractant for fibroblasts, smooth muscle cells, glial cells, monocytes, and neutrophils.
Immunogen
PDGF receptor-β, PDGFR-β, platelet-derived growth factor receptor beta
Species Reactivity
Mouse
Clonality
Monoclonal
Host Species
Rat
Isotype
IgG2a, κ
Clone Number
CBP2282
Applications
FC
Application Notes
FCM (≤1.0 µg per million cells in 100 µl volume)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation
Conjugation
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1683
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
0.2 mg/ml
Purification
Affinity chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Endotoxin Level
Low Endotoxin
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Handling Advice
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Target
PDGFRB
Official Name
PDGFRB
Full Name
Platelet-derived growth factor receptor beta
Alternative Names
PDGFRB; CD140B; IBGC4; IMF1; JTK12; PDGFR; PDGFR-1; PDGFR1; KOGS; PENTT; platelet derived growth factor receptor beta
References
1. Soriano P, et al. 1994. Genes Dev. 8:1888
2. Takakura N, et al. 1996. J Invest Dermatol. 107:770
3. Yarden Y, et al. 1986. Nature 323:226
2. Takakura N, et al. 1996. J Invest Dermatol. 107:770
3. Yarden Y, et al. 1986. Nature 323:226
Publications
Publications (0)
Neural Antibodies
Cell Assay Reagents
For Research Use Only. Not For Clinical Use.
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