NeuroMab™ Anti-PDGFRB Antibody(NRP-0422-P1974)

Product Overview

Description

The antibody is a fully human antibody that bind to human PDGFR-beta with high affinity. The antibody is useful for the treatment of diseases and disorders associated with PDGFR-beta signaling and/or PDGFR-beta cellular expression, such as ocular diseases, fibrotic diseases, vascular diseases and cancer.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Human

Applications

Inhib; Block; In Vitro; In Vivo

Relevant Diseases

Tumor

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

> 95% (SDS-PAGE)

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

PDGFRB

Official Name

PDGFRB

Full Name

Platelet-derived growth factor receptor beta

Alternative Names

PDGFRB; CD140B; IBGC4; IMF1; JTK12; PDGFR; PDGFR-1; PDGFR1; KOGS; PENTT; platelet derived growth factor receptor beta

Gene ID

5159

Uniprot ID

P09619

Product Pictures

Block

Figure 1 is a histogram showing the results of a PDGF ligand blocking assay in which PDGFR-β was captured on the biosensor surface and PDGF ligands (BB, DD or AB) were blocked after treatment with various anti-PDGFR-β antibodies. Apply to surface. Results are displayed in RU.

FuncS

Figure 2 is a matrix showing the results of an antibody cross-competition assay in which a first anti-PDGFR-β antibody (mAb#1) was applied to a PDGFR-β-coated sensor tip and then treated with a second anti-PDGFR - Beta antibody (mAb#2).

Publications