NeuroMab™ Mouse Anti-CD45 Monoclonal Antibody (CBP2348)
[CAT#: NAB2010338LS]
Anti-CD45 Monoclonal Antibody [Alexa Fluor 594]
- Host Species:
- Mouse
- Species Reactivity:
- Human; African green monkey; Baboon; Cynomolgus; Rhesus
- Applications:
- IHC-P
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
CD45RB is a 180-240 kD single chain type I membrane glycoprotein. It is an exon 5 splice variant of the tyrosine phosphatase CD45. The CD45RB isoform is expressed on thymocytes, T cell subsets, B cells, monocytes/macrophages, granulocytes, and dendritic cells. CD45RB enhances both T cell receptor and B cell receptor signaling mediated activation. CD45 and its isoforms non-covalently associate with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD45 has also been reported to bind galectin-1. CD45 isoform expression can change in response to cytokines. The MEM-55 antibody recognizes a silaidase-sensitive epitope of CD45.
Immunogen
Human thymocytes and T lymphocytes
Species Reactivity
Human; African green monkey; Baboon; Cynomolgus; Rhesus
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG2b, κ
Clone Number
CBP2348
Applications
IHC-P
Application Notes
IHC-P (5.0 - 10.0 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation
Conjugation
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1733
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Endotoxin Level
Low Endotoxin
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Handling Advice
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
References
1. Thomas M. 1989. Annu. Rev. Immunol. 7:339.
2. TroWBridge I, et al. 1994. Annu. Rev. Immunol.12:85.
2. TroWBridge I, et al. 1994. Annu. Rev. Immunol.12:85.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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