NeuroMab™ Mouse Anti-Marmoset CD45 Monoclonal Antibody (CBP2240)
[CAT#: NAB2010148LS]
Anti-CD45 Monoclonal Antibody [Biotin]
- Host Species:
- Mouse
- Species Reactivity:
- Marmoset
- Applications:
- FC
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
CD45 is a 180-240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes and platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4.
Immunogen
Marmoset mononuclear cells
Species Reactivity
Marmoset
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1
Clone Number
CBP2240
Applications
FC
Application Notes
FCM (≤0.5 µg per million cells in 100 µl volumel)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Endotoxin Level
Low Endotoxin
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
Handling Advice
The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
References
1. Thomas M. 1989. Annu. Rev. Immunol. 7:339.
2. TroWBridge I and Thomas M. 1994. Annu. Rev. Immunol. 12:85.
2. TroWBridge I and Thomas M. 1994. Annu. Rev. Immunol. 12:85.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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