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Creative Biolabs
Product

NeuroMab™ Mouse Anti-Marmoset CD45 Monoclonal Antibody (CBP2240)

[CAT#: NAB2010148LS]

Anti-CD45 Monoclonal Antibody [Biotin]

Host Species:
Mouse
Species Reactivity:
Marmoset
Applications:
FC

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Product Overview

Description

CD45 is a 180-240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes and platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4.

Immunogen

Marmoset mononuclear cells

Species Reactivity

Marmoset

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2240

Applications

FC

Application Notes

FCM (≤0.5 µg per million cells in 100 µl volumel)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1662
Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.

Handling Advice

The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.

Research Use Only

For research use only, not for diagnostic or therapeutic use.
Target

Target

CD45

Official Name

PTPRC

Full Name

Protein tyrosine phosphatase, receptor type, C

Alternative Names

LCA; T200

Gene ID

5788 (Human); 19264 (Mouse)

Uniprot ID

P08575 (Human); P08575 (Mouse)
References

1. Thomas M. 1989. Annu. Rev. Immunol. 7:339.
2. TroWBridge I and Thomas M. 1994. Annu. Rev. Immunol. 12:85.
Publications

Publications (0)

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For Research Use Only. Not For Clinical Use.
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