NeuroMab™ Rat Anti-Human Cytokeratin 17 Monoclonal Antibody (CBP2461)

Product Overview

Description

Cytokeratin 17 (CK-17), also known as KRT17 or keratin-17 (K-17), is a type I intermediate filament protein. KRT expression is normally restricted to ectoderm-derived epithelial appendages such as thymus, glands, skin, hair, tooth, nail, and the endocervical mucosa. Cytokeratin-17 participates in promoting protein synthesis and cell growth through recruiting stratifin (SFN) to the cytoplasm and stimulating the Akt/mTOR pathway. Cytokeratin-17 was found to regulate chemokine expression, including the CXCR3 ligands CXCL9, CXCL10, and CXCL11. Cytokeratin 17 expression can be upregulated in response to chemical stimulation, wounding, and UV irradiation. Increased expression of Cytokeratin 17 is associated with lesion progression and poor prognosis in epithelial carcinoma. Cytokeratin 17 deficient mice show a delay in wound healing and attenuated tumorigenesis.

Immunogen

Human Cytokeratin 17 peptide (415-432 a.a.) conjugated to KLH

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG2b, κ

Clone Number

CBP2461

Applications

WB; ICC

Application Notes

WB (0.05-0.5 µg/mL); ICC (0.2-2.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1801

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

Batch Dependent

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Cytokeratin 17

Official Name

Cytokeratin 17

Full Name

Cytokeratin 17

Alternative Names

Keratin; type I cytoskeletal 17; keratin-17 (K-17); cytokeratin-17 (CK-17); KRT17; CK17; K17

References

1. Hobbs RP, et al. 2016. Oncogene. 35:5653.
2. Escobar-Hoyos LF, et al. 2015. Cancer Res. 75:3650.
3. Chung BM, et al. 2015. J. Cell. Biol. 208:613.
4. Sankar S, et al. 2013. Mol. Cell. Biol. 33:4448.
5. Jin L, et al. 2014. Med. Res. Rev. 34:438.
6. Depianto D, et al. 2010. Nat. Genet. 42:910.

Publications