Rat Anti-Human Cytokeratin-17 Monoclonal Antibody (CBP3760)
[CAT#: NAB2012149LS]
Anti-Cytokeratin-17 Monoclonal Antibody [Alexa Fluor 488 ]
- Host Species:
- Rat
- Species Reactivity:
- Human
- Applications:
- ICC
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
Cytokeratin 17 (CK-17), is a type I intermediate filament protein. Cytokeratin 17 participates in promoting protein synthesis and cell growth through recruiting stratifin (SFN) to the cytoplasm and stimulating the Akt/mTOR pathway. Cytokeratin 17 was found to regulate chemokine expression, including the CXCR3 ligands CXCL9, CXCL10, and CXCL11. Cytokeratin 17 expression can be upregulated in response to chemical stimulation, wounding, and UV irradiation. Increased expression of Cytokeratin 17 is associated with lesion progression and poor prognosis in epithelial carcinoma. Cytokeratin 17 deficient mice show a delay in wound healing and attenuated tumorigenesis.
Immunogen
Human Cytokeratin 17 peptide (415-432 a.a.) conjugated to KLH
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Rat
Isotype
IgG2b, κ
Clone Number
CBP3760
Applications
ICC
Application Notes
ICC (0.5-2.0 μg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Alexa Fluor 594; Alexa Fluor 488; Alexa Fluor 498; Alexa Fluor 647; Alexa Fluor 700; APC; APC/Cyanine 7; APC/Fire 750; Biotin; Brilliant Violet 421; Brilliant Violet 510; Brilliant Violet 570; Brilliant Violet 570; Brilliant Violet 605; Brilliant Violet 650; Brilliant Violet 711; Brilliant Violet 750; Brilliant Violet 785; FITC; HRP; PE; Pacific Blue; PE/Cyanine 5; PE/Cyanine 7; PerCP; Spark YG 570
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Target
Cytokeratin 17
Official Name
KRT17
Full Name
Vimentin
Alternative Names
KRT17; K17; PC; PC2; PCHC1; 39.1; CK-17; keratin 17
References
1. Guerra F, Bucci C. 2016. Cells. 5(3).
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
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