AAV2-NGF Viral Vector [Alzheimer's Disease]

[CAT#: NRP-0322-P2145]

Tracer Type:: Neurological Disease Related Virus; Gene Therapy

Applications:: Neural Tracing

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Description

The AAV2-NGF Viral Vector represents a gene-therapy approach for neuroprotective treatment of Alzheimer's disease. It employed injection of an AAV2-based vector for expression of the gene encoding the trophic protein nerve growth factor (NGF) into the nucleus basalis of Meynert, a cholinergic brain area that degenerates in the disease. The approach grew out of research showing that local NGF delivery was able to slow age-related neurodegeneration in mouse models and rhesus monkeys.