AAV2-NGF Viral Vector [Alzheimer's Disease]
[CAT#: NRP-0322-P2145]
- Tracer Type:
- Neurological Disease Related Virus; Gene Therapy
- Applications:
- Neural Tracing
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SPECIFIC INQUIRY
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Description
The AAV2-NGF Viral Vector represents a gene-therapy approach for neuroprotective treatment of Alzheimer's disease. It employed injection of an AAV2-based vector for expression of the gene encoding the trophic protein nerve growth factor (NGF) into the nucleus basalis of Meynert, a cholinergic brain area that degenerates in the disease. The approach grew out of research showing that local NGF delivery was able to slow age-related neurodegeneration in mouse models and rhesus monkeys.
Tracer Type
Neurological Disease Related Virus; Gene Therapy
Virus Type
Adeno-Associated Virus (AAV)
Applications
Neural Tracing
Properites
Research Use Only
For reseach use only
Publications
Publications (0)
Neural Tracers
For Research Use Only. Not For Clinical Use.
Product
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Cells
- Mouse Microglia from C57BL/6 (Cat#: NCL-21P6-082)
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Kits
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Tracers
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Biospecimens
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
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Cell Assay Reagents
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