Human 1321N1/P2Y1 Stable Cell Line

[CAT#: NCL20120105CR]

P2Y1 Purinergic Receptor Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

P2Y receptors are members of a large family of G protein-coupled receptors that is classified into five functionally characterized human gene products (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11). P2RY1 or P2Y1 is a GPCR that binds to ADP and ATP to activate Gq. P2Y1 express on vascular endothelium and smooth muscle, and mediate vascular tone both in the resting state and in thrombosis, when platelet-derived ATP and ADP are present at high concentrations. In addition, activation of P2Y1 expressed on platelets leads to ADP-induced shape changes and aggregation.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

DMEM, 10% FBS, 200 μg/ml Zeocin

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

P2Y1

Family

P2Y receptor

Strain

1321N1/P2Y1 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

P2Y1

Official Name

P2RY1

Alternative Names

P2Y1 receptor; Purinergic receptor P2Y1; ATP receptor; P2Y purinoceptor 1; platelet ADP receptor; P2 purinoceptor subtype Y1; P2Y; P2Y ATP receptor 1;P2Y purinoceptor 1

Gene ID

5028(Human); 18441(Mouse); 25265(Rat)

Uniprot ID

P47900(Human); P49650(Mouse); P49651(Rat)

References

1. Watanabe, H., Matsushita, N., Shimizu, Y., Iikuni, S., Nakamoto, Y., Togashi, K., & Ono, M. (2019). Synthesis and characterization of a novel 18 F-labeled 2, 5-diarylnicotinamide derivative targeting orexin 2 receptor. MedChemComm, 10(12), 2126-2130.

Publications