Human 1321N1/P2Y2 Stable Cell Line

[CAT#: NCL20120106CR]

P2Y2 Purinergic Receptor Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

The P2Y2 receptor, originally called P2U purinoceptor, recognizes both ATP and UTP as the most potent agonists. It ranges from excitation of sympathetic neurons, muscle cell proliferation, endothelial cell adhesion, and spermiogenesis to acid-base equilibrium in intestinal epithelial cells and mucociliary clearance in normal and cystic fibrosis airway epithelia. In the airways, the P2Y2 and the P2Y6 receptors on the apical surface of airway epithelial cells control several of the calcium and protein kinase C dependent components of mucociliary clearance. The P2Y2 receptor is also expressed on the basolateral cell surface along with the P2Y1 receptor.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

DMEM, 10% FBS, 250 μg/ml G418

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

P2Y2

Family

P3Y receptor

Strain

1321N1/P2Y2 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

P2Y2

Official Name

P2RY2

Alternative Names

P2U; ATP receptor; P2U purinoceptor; P2U1; P2Y ATP receptor 2; P2Y purinoceptor 2

Gene ID

5029(Human); 18442(Mouse); 29597(Rat)

Uniprot ID

P41231(Human); P35383(Mouse); P41232(Rat)

References

1. Montagna, E., Crux, S., Luckner, M., Herber, J., Colombo, A. V., Marinković, P.,.. & Sgobio, C. (2019). In vivo Ca2+ imaging of astrocytic microdomains reveals a critical role of the amyloid precursor protein for mitochondria. Glia, 67(5), 985-998. 2. Xu, Y., Wu, X., Wang, S., Yang, C., Li, Y., & Cao, Y. (2019). Hydroxyapatite Nanoparticle-Crosslinked Peptide Hydrogels for Three-Dimensional Culture and Differentiation of MC3T3-E1 Osteoblasts. Journal of biomedical nanotechnology, 15(12), 2351-2362. 3. Lan, J., Rollins, J. A., Zang, X., Wu, D., Zou, L., Wang, Z.,.. & Chen, D. (2019). Translational regulation of non-autonomous mitochondrial stress response promotes longevity. Cell reports, 28(4), 1050-1062.

Publications