Human CHO-K1/H2/Gα15 Stable Cell Line

[CAT#: NCL20120073CR]

H2 Histamine Receptor Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3, and H4. Specifically, the histamine receptor H2 belongs to the rhodopsin-like family of G protein-coupled receptors. As an integral membrane protein, it stimulates gastric acid secretion and regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR; Neural Cell

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 100 μg/ml Hygromycin B, 200 μg/ml Zeocin

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

H2/HRH2

Family

Histamine receptor

Strain

H2/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

HRH2

Official Name

HRH2

Alternative Names

H2 receptor; H2R; HH2R; Histamine H2 receptor

Gene ID

3274(Human); 15466(Mouse)

Uniprot ID

P25021(Human); P97292(Mouse)

References

1. Ramírez, M. P., Rivera, M., Quiroga-Roger, D., Bustamante, A., Vega, M., Baez, M.,.. & Wilson, C. A. (2017). Single molecule force spectroscopy reveals the effect of BiP chaperone on protein folding. Protein Science, 26(7), 1404-1412. 2. Wang, I., Chen, S. Y., & Hsu, S. T. D. (2015). Unraveling the folding mechanism of the smallest knotted protein, MJ0366. The Journal of Physical Chemistry B, 119(12), 4359-4370.

Publications