Human CHO-K1/H4/Gα15 Stable Cell Line

[CAT#: NCL20120075CR]

H4 Histamine Receptor Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

Histamine receptor family consists of four members, namely, H1, H2, H3, and H4. The histamine H4 receptor is the most recently identified G protein-coupled histamine receptor that binds to several neuroactive drugs, including amitriptyline and clozapine. So far, H4 receptors have been found only on haematopoietic cells. This signifies its important role as a drug target for the treatment of inflammatory diseases.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR; Neural Signal Transduction

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 100 μg/ml Hygromycin B, 400 μg/ml G418

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

H4/HRH4

Family

Histamine receptor

Strain

H4/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

HRH4

Official Name

HRH4

Alternative Names

H4 receptor; GPRv53; HH4R; GPCR105; AXOR35; SP9144; H4R; histamine H4 receptor

Gene ID

59340(Human); 225192(Mouse)

Uniprot ID

Q9H3N8(Human); Q91ZY2(Mouse)

References

1. Hamidi, S. R., Safdari, Y., & Arabi, M. S. (2019). Test bacterial inclusion body for activity prior to start denaturing and refolding processes to obtain active eukaryotic proteins. Protein expression and purification, 154, 147-151. 2. Banisadr, A., Safdari, Y., Kianmehr, A., & Pourafshar, M. (2018). Production of a germline-humanized cetuximab scFv and evaluation of its activity in recognizing EGFR-overexpressing cancer cells. Human vaccines & immunotherapeutics, 14(4), 856-863. 3. Pourafshar, M., Safdari, Y., Khajeniazi, S., Yazdani, Y., Banisadr, A., & Veisi, K. (2018). Production and Characterization of Single Chain Nimotuzumab: An In Vitro Study. International Journal of Peptide Research and Therapeutics, 24(1), 171-178.

Publications