Human CHO-K1/OPRL1/Gα15 Stable Cell Line

[CAT#: NCL20120102CR]

Opiate Receptor-like 1 Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

Following the cloning of the classical opioid receptors (mu, delta and kappa), the opiate receptor like-1 (ORL1) was identified as a G-protein coupled receptor (GPCR) with 65% structure homology to the other members of the opioid family. OPRL1 is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ and may be involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. Recently, new study results are consistent with the reported high density of ORL1 receptor mRNA in dorsal raphe nucleus and with inhibitory actions of nociceptin in cells expressing ORL1.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR; Neural Cell

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 400 μg/ml G418, 100 μg/ml Hygromycin B

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

OPRL1

Family

Opioid & opioid-like receptor

Strain

OPRL1/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

Nociceptin

Official Name

OPRL1

Alternative Names

NOP; LY322; N/OFQ receptor; ORL1; OP4; NOCIR; OOR; KOR-3; LC132 receptor-like; orphanin FQ receptor; kappa3-related opioid receptor; KOR3; LC132; MOR-C; OFQR; Oprl; XOR1; ROR-C; kappa-type 3 opioid receptor; nociceptin receptor; nociceptin receptor ORL1; opiate receptor-like 1; opioid receptor-like; orphanin FQ receptor-a; orphanin FQ receptor-b; orphanin FQ receptor-e; peptide receptor; seven transmembrane G protein-coupled receptor; morc; NOP-r; nociceptin/orphanin FQ receptor

Gene ID

4987(Human); 18389(Mouse); 29256(Rat)

Uniprot ID

P41146(Human); P35377(Mouse); P35370(Rat)

References

1. Mi, G., Liu, S., Zhang, J., Liang, H., Gao, Y., Li, N.,.. & Yang, Z. (2017). Levo-tetrahydroberberrubine produces anxiolytic-like effects in mice through the 5-HT 1A receptor. PloS one, 12(1), e0168964.

Publications