NeuroMab™ Anti-ADAM22-extracellular BBB Shuttle Antibody, Clone N57/2

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-ADAM22 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 444-526 (extracellular disintegrin domain) of mouse ADAM22 (also known as Disintegrin and metalloproteinase domain-containing protein 22, Metalloproteinasedisintegrin ADAM22-3, Metalloproteinase-like disintegrin-like and cysteine-rich protein 2 and MDC2, accession number Q9R1V6)
Human: 95% identity (79/83 amino acids identical)
Rat: 100% identity (83/83 amino acids identical)
>50% identity with ADAM11 and ADAM23

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N57/2

Applications

WB; IHC; IP; ICC

Application Notes

Does not cross-react with ADAM11 (based on KO validation results)

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

ADAM22

Official Name

ADAM22

Full Name

ADAM22 (extracellular)

Alternative Names

ADAM22; ADAM 22; MDC2; ADAM metallopeptidase domain 22; EIEE61

Uniprot ID

Q9R1V6

Product Pictures

Fig. 1 Adult rat brain membrane immunoblot.

Fig. 2 Immunoblot versus membranes from postnatal day 8 wild-type (wt) and ADAM22-knockout (ko) mice and probed with N46/30 (left) and N57/2 (right).

Fig. 3 Immunoblot versus brain membranes from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].