NeuroMab™ Anti-Arl13b BBB Shuttle Antibody, Clone N295B/66

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-ARL13B BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 208-427 (C-terminus) of mouse Arl13b (also known as ADP-ribosylation factor-like protein 13B, ADP-ribosylation factor-like protein 2-like 1, ARL2-like protein 1 and Arl2l1, accession number Q640N2)
Rat: 85% identity (189/220 amino acids identical)
Human: 68% identity (154/224 amino acids identical)
<40% identity with Arl13a

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse; Rat

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N295B/66

Applications

WB; IHC; ICC

Research Areas

Rare Disease

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

ARL13B

Official Name

ARL13B

Full Name

Arl13b

Alternative Names

ARL13B; ARL2L1; JBTS8; ADP ribosylation factor like GTPase 13B

Uniprot ID

Q640N2

Product Pictures

Fig. 1 Immunoblot versus crude membranes from adult rat brain (RBM) and pellet/lysate fractions of wild-type (WT) and Arl13b knockout (KO) mouse embryonic fibroblasts (MEF) probed with N295B/66 TC supe (left), rabbit polyclonal (middle) and N52A/42 TC supe (right).