NeuroMab™ Anti-Ataxin-1 wild-type BBB Shuttle Antibody, Clone N65/37

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Ataxin 1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 746-761 (RKRRRWSAPETRKLEK) of mouse ataxin-1 (also known as spinocerebellar ataxia type 1 protein homolog, accession number P54254)
Rat: 93% identity (15/16 amino acids identical)
Human: 87% identity (14/16 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N65/37

Applications

WB; IHC; ICC

Application Notes

No cross-reactivity against phosphoS751-Ataxin-1;Minimal cross-reactivity against S751A mutant of Ataxin-1 by ELISA and immunofluorescence and negative by immunoblot (right)

Research Areas

Rare Disease

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Ataxin 1

Official Name

ATXN1

Full Name

Ataxin-1, WT

Alternative Names

ATXN1; ATX1; D6S504E; SCA1; ataxin 1

Uniprot ID

P54254

Product Pictures

Fig. 1 Transfected cell immunoblot: extracts of COS-1 cells transfected with Ataxin1-WT, Ataxin-1-S751A or Kv2.1 plasmid and probed with N65/37 TC supe.