NeuroMab™ Anti-Bassoon BBB Shuttle Antibody, Clone L124/59

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-BSN BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 157-517 (zinc finger domains) of rat Bassoon (also known as Zinc finger protein 231, BSN, ZNF231 and KIAA0434, accession number O88778)
Mouse: 96% identity (349/363 amino acids identical)
Human: 90% identity (325/361 amino acids identical)
<40% identity with Piccolo

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

L124/59

Applications

WB; IHC; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

BSN

Official Name

BSN

Full Name

Bassoon

Alternative Names

Bassoon Presynaptic Cytomatrix Protein 2 3 5; Zinc Finger Protein 231; Neuronal Double Zinc Finger Protein 2; Protein Bassoon; ZNF231; Bassoon (Presynaptic Cytomatrix Protein) 2; KIAA0434 4;

Uniprot ID

O88778

Product Pictures

Fig. 1 Array tomography immunofluorescence of an LRWhite-embedded 70 nm section from adult mouse cortex with L124/59 (magenta), rabbit mAb PSD-95 and Hoechst nuclear stain (blue). The insert shows three consecutive sections through the synapse that is marked with a white box.