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Creative Biolabs

NeuroMab™ Anti-CXCR4 BBB Shuttle Antibody(NRZP-1022-ZP3783)

[CAT#: NRZP-1022-ZP3783]

Host Species:
Humanized
Species Reactivity:
Human
Applications:
ADCC; CDC; FC; In Vitro; In Vivo

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Humanized

Isotype

lgG1

Applications

ADCC; CDC; FC; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease; Parkinson's Disease
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

CXCR4

Official Name

CXCR4

Full Name

C-X-C Motif Chemokine Receptor 4

Alternative Names

NR2F1; BBOAS; BBSOAS; COUP-TFI; EAR-3; EAR3; ERBAL3; NR2F2; SVP44; TCFCOUP1; TFCOUP1; nuclear receptor subfamily 2 group F member 1; COUPTF1
Product Pictures
FuncS

Figure 1 shows the cross-reactivity of the anti-human CXCR4 antibody h3G10.1.91.A58B to cynomolgus monkey CXCR4 by flow cytometry in a dilution series (0.007-267 nM) against HPB-ALL (human T-cell leukemia) and Cyno- CXCR4-transfected CHO cells were analyzed.

FuncS

Figure 2 shows the effect of anti-human CXCR4 antibody h3G10.1.91.A58B on Raji (NHL; human non-Hodgkin's lymphoma) and HSC-F (cynomolgus monkey T cell line).

ADCC

Figure 3 shows the ADCC activity of 12A11, 6B6 and 3G10 anti-human CXCR4 antibodies on Ramos (NHL) cells.

ADCC

Figure 4 shows a comparison of ADCC activities of m3G10-hlgG1 and m3G10-hlgG4 anti-human CXCR4 antibodies on MOLT-4 (T-acute lymphoblastic leukemia) cells.

FuncS

Figure 5 shows inhibition of calcium flux by 3G10, 6B6 and 12A11 anti-human CXCR4 antibodies.

FuncS

Figure 6 shows that 3G10, 6B6 and 12A11 anti-human CXCR4 antibodies significantly inhibited tumor growth in a non-Hodgkin's lymphoma (NHL) model (Ramos) compared to an isotype control antibody.

FuncS

Figure 7 shows that anti-human CXCR4 antibodies 3G10, 6B6 and 12A11 had a significant effect on tumor burden in animals systemically implanted with Raji-LUC cells compared to an isotype control antibody.

FuncS

Figure 8 is a survival curve showing the significant effect of anti-human CXCR4 antibodies 3G10, 6B6 and 12A11 compared to an isotype control antibody on the survival of animals systemically implanted with Raji-LUC cells.

FuncS

Figure 9 shows that humanized anti-human CXCR4 antibody significantly inhibits tumor growth in a non-Hodgkin's lymphoma (NHL) model (Ramos) compared to an isotype control antibody.

FuncS

Figure 10 shows the significant antitumor effect of CXCR4 ADCs 3G10-TG6-vc0101 and 6B6-TG6-vc0101 in Ramos (NHL) tumor model.

FuncS

Figure 11 shows the significant anti-tumor effect of CXCR4 ADC 3G10-TG6-vc0101 in HPB-ALL (T-ALL) tumor model.

FuncS

Figure 12 shows the bioluminescence (fluorescein Enzyme activity) quantification

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