Mouse Anti-CXCR4 Monoclonal Antibody (CBP2602)

Product Overview

Description

C-X-C chemokine receptor type 4 (CXCR4) is a widely expressed G protein-coupled seven-transmembrane receptor. CXCL12/SDF-1 is the biological ligand for CXCR4. The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals related to chemotaxis, cell survival and/or proliferation, increase in intracellular calcium, and gene transcription (PMID: 20484021). CXCR4 also functions as a coreceptor for HIV-1 entry (PMID: 9427609).

Expression Host

Mammalian cells

Immunogen

CXCR4 fusion protein Ag1528

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgM

Clone Number

CBP2602

Applications

FC; WB; ELISA

Application Notes

WB : 1:500-1:1000

Research Areas

Neural Signal Transduction

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1500 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CXCR4

Official Name

CXCR4

Full Name

Chemokine (C-X-C motif) receptor 4

Alternative Names

CD184; CXC R4; CXCR 4; CXCR4; CXCR4B; D2S201E; FB22; Fusin; HM89; HSY3RR; LAP3; LCR1; LESTR; SDF 1 receptor; WHIM

Gene ID

7852(Human); 12767(Mouse)

Uniprot ID

P61073(Human); P70658(Mouse)

References

1. Cheng, Y., Yin, B., Hou, T., Chen, T., & Ping, J. (2019). The overexpression of GRASP might inhibit cell proliferation and invasion in hepatocellular carcinoma. Journal of Cellular Physiology, 234(9), 16215-16225. 2. Shi, W. L., Zhao, J., Yuan, R., Lu, Y., Xin, Q. Q., Liu, Y.,... & Chen, K. J. (2019). Combination of ligusticum chuanxiong and radix paeonia promotes angiogenesis in ischemic myocardium through notch signalling and mobilization of stem cells. Evidence-Based Complementary and Alternative Medicine, 2019. 3. Liu, R., Wang, W., Dai, B., Liu, Y., & Zhang, Y. (2015). Taspine derivative TAS9 regulates cell growth and metastasis of human hepatocellular carcinoma. Molecular medicine reports, 12(5), 7735-7741.

Publications