Human CHO-K1/CXCR4/Gα15 Stable Cell Line

[CAT#: NCL20120044CR]

CXCR4 Receptor Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

CXCR4 is a receptor for the C-X-C chemokine SDF-1 (Stromal Cell-Derived Factor 1). It is involved in haematopoiesis and cardiac ventricular septum formation, and plays an essential role in vascularization of the gastrointestinal tract, cerebellar development and survival of hippocampal-neuron of central nerve system. CXCR4 also acts as a primary receptor for some HIV-2 isolates and as a co-receptor with CD4 for HIV-1 X4 viruses.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 3 μg/ml puromycin, 100 μg/ml Hygromycin B

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

CXCR4

Family

Chemokine receptor

Strain

CXCR4/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

CXCR4

Official Name

CXCR4

Alternative Names

CXCR4; CD184

Gene ID

7852(Human); 12767(Mouse)

Uniprot ID

P61073(Human); P70658(Mouse)

References

1. McKernan, K. J., Helbert, Y., Kane, L. T., Ebling, H., Zhang, L., Liu, B.,.. & Concepcion, G. (2020). Sequence and annotation of 42 cannabis genomes reveals extensive copy number variation in cannabinoid synthesis and pathogen resistance genes. BioRxiv. 2. Wayengera, M., Mwebaza, I., Welishe, J., Bayiyana, A., Kateete, D. P., Wampande, E.,.. & Kyobe, S. (2017). Immuno-diagnosis of Mycobacterium tuberculosis in sputum, and reduction of timelines for its positive cultures to within 3 h by pathogen-specific thymidylate kinase expression assays. BMC research notes, 10(1), 368.

Publications