NeuroMab™ Anti-CXCR4 BBB Shuttle Antibody(NRZP-1022-ZP3807)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

FC; Inhib

Relevant Diseases

Alzheimer's Disease; Parkinson's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

CXCR4

Official Name

CXCR4

Full Name

C-X-C Motif Chemokine Receptor 4

Alternative Names

NR2F1; BBOAS; BBSOAS; COUP-TFI; EAR-3; EAR3; ERBAL3; NR2F2; SVP44; TCFCOUP1; TFCOUP1; nuclear receptor subfamily 2 group F member 1; COUPTF1

Product Pictures

FCM

Figure 1 shows the titration of anti-CXCR4 scFv-Fc fusion protein with Jurkat cell line.

FCM

Figure 2 is a series of graphs demonstrating the ability of scFv fusion proteins to block entry of a single round of pseudotyped HIV-1 into target cells.

Luciferase activity (cpm) was measured after 48 hours. Inhibitory capacity was calculated as the average of triplicate wells: (average cpm of experimental wells/average cpm of wells not treated with antibody before virus addition) × 100%. The X4 tropical HIV-1 pseudovirus Hxbc-2 was tested in this experiment.