NeuroMab™ Anti-CXCR4 BBB Shuttle Antibody(NRZP-1022-ZP3817)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

Inhib; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease; Parkinson's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

CXCR4

Official Name

CXCR4

Full Name

C-X-C Motif Chemokine Receptor 4

Alternative Names

NR2F1; BBOAS; BBSOAS; COUP-TFI; EAR-3; EAR3; ERBAL3; NR2F2; SVP44; TCFCOUP1; TFCOUP1; nuclear receptor subfamily 2 group F member 1; COUPTF1

Product Pictures

FuncS

Figure 1 illustrates the study of [35S]GTPγS binding to the membrane of CHO-K1 cells constitutively expressing the human CXCR4 receptor effects of SDF1 and antibody 44717.