NeuroMab™ Anti-Dopamine D3 receptor BBB Shuttle Antibody, Clone N331/19

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Dopamine Receptor D3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 223-322 (third intracellular loop) of human Dopamine D3 receptor (also known as Dopamine receptor D3 and DRD3, accession number P35462)
Mouse:>50% identity (81/126 amino acids identical)
Rat:>50% identity (76/147 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N331/19

Applications

WB; IHC; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Dopamine Receptor D3

Official Name

DRD3

Full Name

Dopamine D3 receptor

Alternative Names

DRD3; D3DR; ETM1; FET1; dopamine receptor D3

Uniprot ID

P35462

Product Pictures

Fig. 1 Transfected cell immunofluorescence: COS cells expressing untagged human Dopamine D3 receptor with GFP. Red=N331/10, Green=GFP, Blue=Hoechst nuclear stain.

Publications