NeuroMab™ Anti-FGFR2 BBB Shuttle Antibody(NRZP-1022-ZP3902)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Human

Applications

In Vitro; In Vivo

Relevant Diseases

Neuroinflammation

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

FGFR2

Official Name

FGFR2

Full Name

Fibroblast Growth Factor Receptor 2

Alternative Names

Fibroblast Growth Factor Receptor 2; Keratinocyte Growth Factor Receptor; Bacteria-Expressed Kinase; EC 2.7.10.1; K-SAM; KGFR; BEK; Protein Tyrosine Kinase; Receptor Like 14; BEK Fibroblast Growth Factor Receptor; Craniofacial Dysostosis 1; Jackson-Weiss Syndrome; Pfeiffer Syndrome; Crouzon Syndrome; CD332 Antigen;

Product Pictures

FuncS

Figure 1: Induction level of phosphorylated FGFR2 (P-FGFR2) in MFM223 after a short (15 min) incubation with 10 μg/ml anti-FGFR2 antibody. Y is the % of untreated and control cells

FuncS

Figure 2: After long-term incubation (24 hours) with 10 μg/ml anti-FGFR2 antibody, the induction of FGF7 (25ng/ml, 15min)-mediated P-FGFR2 levels in MFM223 cells is desensitized. Y is compared with control cells Unprocessed percentage

FuncS

Figure 3: FGFR2 surface expression was downregulated in FGFR2 overexpressing (MFM223, SNU16) or FGFR2 mutant (AN3-CA, MFE-296) cell lines after 4.5 hours of incubation with 10 μg/ml anti-FGFR2 antibody (investigated by FACS analysis).

FuncS

Figure 4: Total FGFR2 levels decreased after prolonged incubation (96 hours) with anti-FGFR2 antibodies in SNU16 cells.

FuncS

Figure 5: Microscopic evaluation of the time course of the specific internalization of M048-D01-hIgG1 and M047-D08-hIgG1 after binding to cells expressing endogenous FGFR2.