Mouse Anti-FGFR3 Monoclonal Antibody (CBP2877)

Product Overview

Description

Fibroblast growth factors (FGFs) are polypeptide growth factors involved in a variety of activities including mitogenesis, angiogenesis, and wound healing. Each receptor contains an extracellular domain with either two or three immunoglobulin-like domains, a transmembrane domain, and a cytoplasmic tyrosine kinase domain. FGFR3 binds acidic and basic fibroblast GH and plays a role in bone development and maintenance. Mutations in the FGFR3 gene lead to craniosynostosis and multiple types of skeletal dysplasia. Due to frequent mutations in certain cancers, FGFR3 gene has also been associated with tumor progression.

Expression Host

Mammalian cells

Immunogen

FGFR3 fusion protein Ag26290

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2877

Applications

WB; ELISA

Application Notes

WB : 1:500-1:1000

Research Areas

Neurotransmission

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

FGFR3

Official Name

FGFR3

Full Name

Fibroblast growth factor receptor 3

Alternative Names

ACH; CD333; CEK2; FGFR 3; FGFR3; HSFGFR3EX; JTK4

References

1. Kuang, L., Wu, J., Su, N., Qi, H., Chen, H., Zhou, S.,... & Jin, M. (2020). FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophages via upregulating CXCR7 and aggravates joint destruction in mice. Annals of the Rheumatic Diseases, 79(1), 112-122.

Publications