NeuroMab™ Anti-KA2 kainate receptor BBB Shuttle Antibody, Clone N279B/27

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GluK5 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 825-979 (cytoplasmic C-terminus) of rat KA2 kainate receptor (also known as Glutamate receptor ionotropic, kainate 5, Glutamate receptor gamma-2, GluR gamma-2, Excitatory amino acid receptor 2, Grik5, GluK5 and EAA2, accession number Q63273)
Mouse: 100% identity (155/155 amino acids identical)
Human: 95% identity (149/156 amino acids identical)
<50% identity with KA1

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N279B/27

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with KA1

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

GluK5

Official Name

GRIK5

Full Name

GluK5/Grik5/KA2 kainate receptor

Alternative Names

GRIK5; EAA2; GRIK2; GluK5; KA2; glutamate ionotropic receptor kainate type subunit 5

Uniprot ID

Q63273

Product Pictures

Fig. 1 Immunoblot against crude brain membrane preparations from adult rat (RBM) or wild-type (WT) or KA2 knockout (KO) mice probed with N279B/27 (left) or N52A/42 (right) TC supe.

Publications