NeuroMab™ Anti-Kvβ1.2 potassium channel subunit BBB Shuttle Antibody, Clone K47/42

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNAB1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 9-28 (ADIPSPKLGLPKSSESALKC, unique Nterminus) of human Kv1.2 (accession number NP_003462)
Rat: 100% identity (20/20 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

K47/42

Applications

WB; IHC; IP; ICC

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCNAB1

Official Name

KCNAB1

Full Name

Kvbeta1.2/KCNAB1 K+ channel

Alternative Names

KCNAB1; AKR6A3; KCNA1B; KV-BETA-1; Kvb1.3; hKvBeta3; hKvb3; potassium voltage-gated channel subfamily A member regulatory beta subunit 1

Uniprot ID

Q14722-3

Product Pictures

Fig. 1 Immunoblot of crude membrane fractions from adult heart ventricle (V) and brain (B) from wild-type (WT) and Kvβ1 knockout (Kvβ1) mice probed with K47/42 (Kvβ1.2, top) and K17/70 (Kvβ2, bottom).

IHC

Fig. 2 Adult rat hippocampus immunohistochemistry.

Fig. 3 Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human cerebellum [HBM(Cb)], cerebral cortex [HBM(Cx)] or hippocampus [HBM(H)] and probed with K37/89 (left) or N52A/42 (right) TC supe.