NeuroMab™ Anti-Pan-SAPAP BBB Shuttle Antibody, Clone N127/31

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-SAPAP BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 772-992 (C-terminus) of rat SAPAP1 (also known as disks large-associated protein 1, guanylate kinase-associated protein, GKAP, SAP90/PSD-95-associated/binding protein 1, accession number P97836)
Mouse: 99% identity (200/201 amino acids identical)
Human: 99% identity (199/201 amino acids identical) 55-65% identity with other SAPAPs

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

N127/31

Applications

WB; IHC; ICC

Application Notes

Cross-reacts with other SAPAPs

Research Areas

Scaffolds

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

SAPAP

Official Name

Pan-SAPAP

Full Name

Pan-SAPAP

Alternative Names

Synapse-Associated Protein 90/Postsynaptic Density-95-Associated Protein

Product Pictures

Fig. 1 Immunoblots on membranes prepared from whole mouse (MBM) and rat (RBM) brain, and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)], and cerebellum [HBM(Cb)].

Fig. 2 Adult RBM and transfected cell immunoblot: extracts of RBM and COS cells transiently transfected with Flag-tagged SAPAP1, SAPAP4 or untagged Kv2.1 plasmids and probed with N127/31 TC supe.

Fig. 3 Cultured rat hippocampal pyramidal cell (left) and interneuron (right) immunofluorescence staining. N127/31 (Pan-SAPAP)=green, rabbit anti-PSD-95=red.