NeuroMab™ Anti-PINK1 BBB Shuttle Antibody, Clone N4/49

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-PINK1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 112-496 (cytoplasmic C-terminus) of human PINK1 (also known as PTEN-induced putative kinase protein 1, Serine/threonineprotein kinase PINK1, mitochondrial and BRPK, accession number Q9BXM7)
Rat: 82% identity (316/385 amino acids identical)
Mouse: 81% identity (312/385 amino acids identical)
<30% identity with DMPK

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N4/49

Applications

WB; IHC; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

PINK1

Official Name

PINK1

Full Name

PINK1

Alternative Names

PTEN Induced Putative Kinase 1; PTEN-Induced Putative Kinase Protein 1; BRPK; Serine/Threonine-Protein Kinase PINK1; Mitochondrial; Parkinson Disease (Autosomal Recessive) 6; Protein Kinase BRPK; EC 2.7.11.1; PARK6;