NeuroMab™ Anti-PSD-95 MAGUK scaffold protein BBB Shuttle Antibody, Clone K28/43

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-PSD 95 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 77-299 (PDZ domains 1 and 2) of human PSD-95 (also known as Postsynaptic density protein 95, Disks large homolog 4, Synapse-associated protein 90, DLG4, Dlgh4 and SAP-90, accession number P78352)
Rat: 100% identity (223/223 amino acids identical)
Mouse: 99% identity (221/223 amino acids identical)
65-80% identity with DLG1/SAP97,
DLG2/Chapsyn-110 and DLG3/SAP102

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

K28/43

Applications

WB; IHC; IP; ICC

Application Notes

Does not cross-react with DLG1/SAP97, DLG2/Chapsyn-110 or DLG3/SAP102

Research Areas

Scaffolds

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

PSD 95

Official Name

DLG4

Full Name

PSD-95

Alternative Names

DLG4; PSD95; SAP-90; SAP90; Dlgh4; PSD-95; SAP90A; discs large homolog 4; discs large MAGUK scaffold protein 4; MRD62

Uniprot ID

P78352

Product Pictures

IEM

Fig. 1 Electron micrograph of K28/43 hippocampal labelling using a post-embedding immunogold method. Immunoparticles (arrows) are seen in the postsynaptic densities of dendritic spines (s) forming asymmetrical synapses with axon terminals (b).

Fig. 2 Immunoblot against adult rat brain membranes (RBM) and adult mouse hippocampal membranes (MHM) from PSD-95 and -93 knockout (KO) mice probed with K28/43 (left) or K28/86 (right) TC supe.

Fig. 3 Immunofluorescence staining of cultured rat hippocampal neurons with K28/43 (green) and K57/1 (red, Kv4.2), right image is higher magnification of left image (dotted lines).