NeuroMab™ Anti-RGS14 BBB Shuttle Antibody, Clone N133/21

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-RGS14 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-544 (full-length) of rat RGS14 (also known as Regulator of G-protein signaling 14, RAP1/RAP2-interacting protein and RPIP1, accession number O08773)
Mouse: 95% identity (524/547 amino acids identical)
Human: 86% identity (475/547 amino acids identical)
<45% identity with RGS12 and other RGS proteins
Epitope mapped to within amino acids 444-490
Mouse: 85% identity (40/47 amino acids identical)
Human: 51% identity (24/47 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse; Rat

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N133/21

Applications

WB; IHC; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

RGS14

Official Name

RGS14

Full Name

RGS14

Alternative Names

RGS14; regulator of G protein signaling 14

Uniprot ID

O08773

Product Pictures

Fig. 1 Immunoblot against lysates from wild-type (+/+) and RGS14 knockout (-/-) mouse brains probed with N133/21.

Fig. 2 Immunoblot against crude membranes from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with N133/21 (left) or N52A/42 (right) TC supe.