NeuroMab™ Anti-SAPAP1 BBB Shuttle Antibody, Clone N238/29

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-DLGAP1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 772-992 (C-terminus) of rat SAPAP1 (also known as disks largeassociated protein 1, DAP-1, guanylate kinase-associated protein, GKAP, SAP90/PSD-95- associated/binding protein 1 and Dlgap1, accession number P97836)
Mouse: 99% identity (200/201 amino acids identical)
Human: 99% identity (199/201 amino acids identical)
>50% identity with SAPAP2 and other SAPAPs

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N238/29

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with SAPAP2, SAPAP3 or SAPAP4

Research Areas

Scaffolds

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

DLGAP1

Official Name

DLGAP1

Full Name

SAPAP1

Alternative Names

DLG Associated Protein 1; Discs Large Homolog Associated Protein 1; Guanylate Kinase-Associated Protein; SAP90/PSD-95-Associated Protein 1; SAPAP1; DAP-1; DAP1; GKAP; Discs; Large (Drosophila) Homolog-Associated Protein 1;