NeuroMab™ Anti-SUR2A BBB Shuttle Antibody, Clone N319A/14

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-ABCC9 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1505-1546 (SSIVDAGLVLVFSEGILVECDTGPNLLQHKNGLFSTLVMTNK, cytoplasmic C-terminus) of mouse SUR2A (also known as Sulfonylurea receptor 2A, ATP-binding cassette transporter sub-family C member 9A and Abcc9A, accession number P70170)
Rat: 97% identity (41/42 amino acids identical)
Human: 92% identity (39/42 amino acids identical)
100% identity with SUR2C
<50% identity with SUR2B

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N319A/14

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with SUR2B

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

ABCC9

Official Name

ABCC9

Full Name

SUR2A

Alternative Names

ATP Binding Cassette Subfamily C Member 9; Sulfonylurea Receptor 2; ATP-Binding Cassette; Sub-Family C (CFTR/MRP); Member 9; SUR2; ATP-Binding Cassette Transporter Sub-Family C Member 9; ATP-Binding Cassette Sub-Family C Member 9;