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Creative Biolabs

NeuroMab™ Anti-TNC BBB Shuttle Antibody(NRZP-1022-ZP2689)

[CAT#: NRZP-1022-ZP2689]

Host Species:
Mouse
Species Reactivity:
Human
Applications:
ELISA; IHC; Inhib; In Vitro; In Vivo

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

ELISA; IHC; Inhib; In Vitro; In Vivo

Relevant Diseases

Cerebrovascular Diseases; Neurodegenerative Diseases
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

TenascinC

Official Name

TNC

Full Name

Tenascin C

Alternative Names

TNC; 150-225; DFNA56; GMEM; GP; HXB; JI; TN; TN-C; Tenascin C
Product Pictures
FuncS

Fig.1 Specific binding of ST2485 to human tenascin and Tn (A (1-4) -D) fragments by Western blot analysis.

Vehicle versus 1 mg/kg, 3 mg/kg and 10 mg/kg C3 antibody. Data are presented as Mean±SEM. Statistical significances: ## p<0.01 and #### p<0.0001 when compared to Day 0, * p<0.05 and ** p<0.01 when compared to the vehicle-treated group.

ELISA

Fig.2 Competition ELISA between ST2485 and BC-2 for binding to tenascin C fragment.

Vehicle versus 1 mg/kg, 3 mg/kg and 10 mg/kg C3 antibody. Data are presented as Mean±SEM. Statistical significances: ## p<0.01 and #### p<0.0001 when compared to Day 0, * p<0.05 and ** p<0.01 when compared to the vehicle-treated group.

ELISA

Fig.3 Competition ELISA between ST2485 and BC-2 for binding to tenascin C fragment.

Vehicle versus 1 mg/kg, 3 mg/kg and 10 mg/kg C3 antibody. Data are presented as Mean±SEM. Statistical significances: ## p<0.01 and #### p<0.0001 when compared to Day 0, * p<0.05 and ** p<0.01 when compared to the vehicle-treated group.

FuncS

Fig.4 In vivo additivity of antibodies ST2485 and ST2146, expressed in ng of antibody localized per gram of tumor.

Vehicle versus 1 mg/kg, 3 mg/kg and 10 mg/kg C3 antibody. Data are presented as Mean±SEM. Statistical significances: ## p<0.01 and #### p<0.0001 when compared to Day 0, * p<0.05 and ** p<0.01 when compared to the vehicle-treated group.

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For Research Use Only. Not For Clinical Use.
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