NeuroMab™ Mouse Anti-Rat SPTBN2 Monoclonal Antibody (CBP2364)

Product Overview

Description

Spectrin β1 (SPTB1) is one of the several beta-spectrins that constitute the major components of the cytoskeletal network in erythrocyte plasma membrane. It binds another structural protein, band 4.1, to form a complex that anchors to the cytoplasmic face of the plasma membrane via Ankyrin, which in turn binds to protein band 3. Mutations in spectrin have been linked to hereditary defects in the erythrocyte, such as hereditary elliptocytosis. Recent studies show that caspase- and calpain-mediated cleavage of spectrin leads to the production of a series of fragments collectively called spectrin breakdown products (SBDPs). Multiple studies have shown that SBDPs may serve as a biomarker for traumatic brain injury (TBI)4.

Species Reactivity

Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP2364

Applications

Application Notes

WB (2-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1745

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

1.0 mg/ml

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.

Handling Advice

Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

SPTBN2

Official Name

SPTBN2

Full Name

Spectrin Beta, Non-Erythrocytic 2

Alternative Names

Spectrin Beta; Non-Erythrocytic 2; Spinocerebellar Ataxia 5 Protein; Beta-III Spectrin; SCA5; Glutamate Transporter EAAT4-Associated Protein 41; Spectrin Beta Chain; Non-Erythrocytic 2; Spectrin; Non-Erythroid Beta Chain 2;