NeuroMab™ Mouse Anti-SPTBN2 Monoclonal Antibody (CBP2299)

Product Overview

Description

The spectrins are a family of widely distributed cytoskeletal proteins which are involved in actin crosslinking. Spectrin α-chain heterodimerizes with tissue-specific β-chains. It is specifically expressed in nonerythrocytic cells. The protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in the gene are the cause of early infantile epileptic encephalopathy. Fodrin, a spectrin that seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus a candidate for the calcium-dependent movement of the cytoskeleton at the membrane.

Species Reactivity

Human; Mouse; Rat; Drosophila

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP2299

Applications

IHC-P

Application Notes

IHC (1.0-10 μg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1694

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Handling Advice

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

SPTBN2

Official Name

SPTBN2

Full Name

Spectrin Beta, Non-Erythrocytic 2

Alternative Names

Spectrin Beta; Non-Erythrocytic 2; Spinocerebellar Ataxia 5 Protein; Beta-III Spectrin; SCA5; Glutamate Transporter EAAT4-Associated Protein 41; Spectrin Beta Chain; Non-Erythrocytic 2; Spectrin; Non-Erythroid Beta Chain 2;