NeuroMab™ Mouse Anti-Human Dynactin 1 (CBP2498)

Product Overview

Description

Dynactin 1 is the largest subunit of the macromolecular complex dynactin, which is essential for dynein-mediated retrograde transport of vesicles and organelles. Dynactin 1 is clinically identified as a causative gene for Perry syndrome (PS), which is a neurodegenerative disease characterized by autosomal dominant inheritance, parkinsonism, and central hypoventilation. Mutations in dynactin 1 are also associated with neurodegenerative diseases, such as amyotrophic lateral sclerosis and frontotemporal dementia.

Immunogen

Purified recombinant Dynactin 1 protein fragments expressed in E.coli.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP2498

Applications

Application Notes

WB (2-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1828

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.10% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

The antibody solution should be stored undiluted between 2°C and 8°C.

Handling Advice

Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

DCTN1

Official Name

DCTN1

Full Name

Dynactin 1

Alternative Names

DAP 150; DCTN1; DP 150; Dynactin subunit 1; HMN7B; P135; p150 glued

Gene ID

1639(Human); 13191(Mouse); 29167(Rat)

Uniprot ID

Q14203(Human); O08788(Mouse); P28023(Rat)

References

1. Konno T, et al. 2017. Parkinsonism Relat Disord. 41:14.
2. Houlden H, et al. 2012. Acta Neuropath. 124(3):325.
3. Tanaka F, et al. 2011. Rinsho Shinkeigaku. 51(11):1189.

Publications