NeuroMab™ Mouse Anti-Cortactin Monoclonal Antibody (CBP2511)
[CAT#: NAB2010653LS]
Anti Cortactin Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human; Rat
- Applications:
- WB; ICC
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
Cortactin is a cytosolic protein that promotes polymerization, rearrangement of the actin cytoskeleton, and synaptogenesis. Stimuli such as alterations in the concentration of growth factors lead to phosphorylation of cortactin by tyrosine or serine/threonine kinases. This modification enables cortactin to bind to filamentous actin and Arp2/3, resulting in the branching of the actin cytoskeleton. In addition, cortactin may be involved in clathrin-independent endocytosis. Amplification of the cortactin gene is observed in certain tumors, indicating that it may also be a component of tumorigenesis.
Species Reactivity
Human; Rat
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1, λ
Clone Number
CBP2511
Applications
WB; ICC
Application Notes
WB (0.5-10 µg/mL); ICC (2-10 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation
Conjugation
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1838
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide
Concentration
1 mg/ml
Purification
Affinity chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Endotoxin Level
Low Endotoxin
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
The antibody solution should be stored undiluted between 2°C and 8°C.
Handling Advice
Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
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