NeuroMab™ Rat Anti-IL-10 Monoclonal Antibody (CBP2530)

Product Overview

Description

Rat anti-human interleukin 10 antibody, recognizes human interleukin 10 (IL-10). IL-10 is expressed by activated CD8 + peripheral blood T cells, activated T helper CD4 + T cell clones, mast cells, B cell lymphomas, and LPS activated monocytes. According to reports, the rat anti-human interleukin-10 antibody JES3-12G8 clone can neutralize the effect of IL-10.

Immunogen

Human IL-10 is expressed by COS cells.

Species Reactivity

Human

Clonality

monoclonal

Host Species

Rat

Isotype

IgG2a

Clone Number

CBP2530

Applications

ELISA; IHC-P; WB

Application Notes

WB: 1/100-1/250, IHC: 1/100
optimal dilutions for assays should be determined by the user.

Relevant Diseases

Amyotrophic Lateral Sclerosis; Frontotemporal Dementia

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1851

Product Properties

Form

Liquid

Formulation

PBS

Preservatives

BSA free

Concentration

1 mg/ml

Purification

Protein G

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

IL-10

Official Name

IL10

Full Name

Interleukin 10

Alternative Names

Interleukin 10

Gene ID

3586(Human)

Uniprot ID

P22301(Human)

References

1. Burdin, N. et al. (1993) Epstein-Barr virus transformation induces B lymphocytes to produce human interleukin 10.
2. Yssel, H. et al. (1992) IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells.
3. Abrams, J.S. et al. (1992) Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples.

Publications