NeuroMab™ Anti-IL10 BBB Shuttle Antibody(NRZP-1022-ZP2885)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

ELISA; In Vitro; In Vivo

Relevant Diseases

Neuroinflammation

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

IL-10

Official Name

IL10

Full Name

Interleukin 10

Alternative Names

Interleukin 10

Product Pictures

ELISA

Figure 1 provides a comparison of the antigen binding properties of humanized antibody variants with chimeric cB-N10 antibody using hIL-10 antigen ELISA.

ELISA

Figure 2 presents the results of an assay of the binding properties of the three humanized variants hVH20/hVL7, hVH20/hVL8 and hVH26/hVL7 compared to chimeric B-N10 antibodies using purified antibody preparations.

ELISA

Figure 3 shows the level of TNFalpha release in whole blood cultures of healthy volunteers after incubation with B-N10 compared to BT-063 (50 μg/ml).

ELISA

Figure 4 shows the release levels of IL-6 from whole blood cultures of healthy volunteers after incubation with B-N10 compared to BT-063 (50 μg/ml).

ELISA

Figure 5 shows the release levels of IL-1beta from whole blood cultures of healthy volunteers after incubation with B-N10 compared to BT-063 (50 μg/ml).