NeuroMab™ Mouse Anti-TLR7 Monoclonal Antibody (CBP2590)
[CAT#: NAB2007FY1110]
Mouse Monoclonal [4F4] to TLR7
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA; WB
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
Mouse anti-human TLR7 antibody, recognizes human TLR7 (toll-like receptor 7), a 121 kDa type I transmembrane protein belonging to the toll-like receptor (TLR) family. TLR7 is mainly expressed in the spleen, lung and placenta (Chuang et al., 2000). TLR is a highly conserved protein. By recognizing the unique molecular patterns expressed by infectious agents, they play a key role in activating innate immunity. TLR7 recognizes the interaction with influenza, HIV-1 (human immunodeficiency virus type I) and Sendai virus-derived single-stranded RNA (ssRNA) and some siRNA, thereby activating the active kinase (IRAK) associated with the MyD88 / interleukin-1 receptor) Signaling pathways, and the production of pro-inflammatory signaling molecules (Diebold et al. 2004).
Immunogen
Recombinant human TLR7 (amino acids 451-5500) purified from E. coli.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1
Clone Number
CBP2590
Applications
ELISA; WB
Application Notes
WB: 1/1000-1/2000
Relevant Diseases
Alzheimer's Disease; Neurodegenerative Disease
Research Areas
Neuroregeneration
Conjugation
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1884
Product Properties
Form
Liquid
Formulation
PBS, 0.02% Sodium Azide, 10% Glycerol
Preservatives
YES
Concentration
1 mg/ml
Purification
Protein G
Endotoxin Level
Low Endotoxin
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
References
1. Kawai, T. & Akira, S. (2006) TLR signaling.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
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