Mouse Anti-Human CD11a Monoclonal Antibody (CBP3917)

[CAT#: NAB2012500LS]

Anti-CD11a Monoclonal Antibody [Alexa Fluor 488 ]

Host Species:: Mouse

Species Reactivity:: Human

Applications:: FC

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Product Overview

Description

CD11a is a 170-180 kD type I transmembrane glycoprotein, also known as LFA-1α chain and integrin αL subunit. CD11a and integrin β2 (CD18) non-covalently bind to form LFA-1. It is expressed on all white blood cells, including B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils. It does not exist on non-hematopoietic tissues and platelets. CD11a plays a central role in the interaction between leukocytes and cells, and is important in lymphocyte costimulation. CD11a/CD18 is combined with ICAM-1 (CD54), ICAM-2 (CD102) and ICAM-3 (CD50).

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP3917

Applications

Application Notes

FCM (5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Alexa Fluor 594; Alexa Fluor 488; Alexa Fluor 498; Alexa Fluor 647; Alexa Fluor 700; APC; APC/Cyanine 7; APC/Fire 750; Biotin; Brilliant Violet 421; Brilliant Violet 510; Brilliant Violet 570; Brilliant Violet 570; Brilliant Violet 605; Brilliant Violet 650; Brilliant Violet 711; Brilliant Violet 750; Brilliant Violet 785; FITC; HRP; PE; Pacific Blue; PE/Cyanine 5; PE/Cyanine 7; PerCP; Spark YG 570

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.

Concentration

1.0 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD11a

Official Name

ITGAL

Full Name

Integrin alpha L

Alternative Names

ITGAL; CD11A; LFA-1; LFA1A; integrin subunit alpha L

Gene ID

3683 (Human); 16408 (Mouse)

Uniprot ID

P20701 (Human); P24063 (Mouse)

References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Lub M, et al. 1995. Immunol. Today 16:479.

Publications