Rat Anti-Mouse CD11a Monoclonal Antibody (CBP4013)

Product Overview

Description

CD11b is a 170 kD glycoprotein, also known as αM integrin, Mac-1α subunit, Mol, CR3 and Ly-40. CD11b is a member of the integrin family and is mainly expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and a subpopulation of T and B cells. CD11b and CD18 (β2 integrin) non-covalently bind to form Mac-1. Mac-1 plays an important role in cell-cell interactions by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b and fibrinogen.

Immunogen

C57BL/6 mouse splenic secondary cytotoxic T cells

Species Reactivity

Mouse

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG2a, κ

Clone Number

CBP4013

Applications

Application Notes

FCM (≤0.25 µg per million cells in 100 µL volume)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.

Concentration

1.0 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD11a

Official Name

ITGAL

Full Name

Integrin alpha L

Alternative Names

ITGAL; CD11A; LFA-1; LFA1A; integrin subunit alpha L

Gene ID

3683 (Human); 16408 (Mouse)

Uniprot ID

P20701 (Human); P24063 (Mouse)

References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Lub M, et al. 1995. Immunol. Today 16:479.

Publications